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Seamless Bead to Microarray Screening: Rapid Identification of the Highest Affinity Protein Ligands From Large Combinatorial Libraries

Several approaches have been developed for screening combinatorial libraries or collections of synthetic molecules for agonists or antagonists of protein function, each with its own advantages and limitations. In this report, we describe an experimental platform that seamlessly couples massively par...

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Detalhes bibliográficos
Main Authors: Astle, John M., Simpson, Levi S., Huang, Yong, Reddy, M. Muralidhar, Wilson, Rosemary, Connell, Steven, Wilson, Johnnie, Kodadek, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905650/
https://ncbi.nlm.nih.gov/pubmed/20142039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.015
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