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Rapid Identification of Improved Protein Ligands Using Peptoid Microarrays

A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via Click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem Lett
Autors principals: Lim, Hyun-Suk, Reddy, M. Muralidhar, Xiao, Xiangshu, Wilson, Johnnie, Wilson, Rosemary, Connell, Steven, Kodadek, Thomas
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452005/
https://ncbi.nlm.nih.gov/pubmed/19380225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.153
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