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Identification of a Peptoid Inhibitor of the Proteasome 19S Regulatory Particle

[Image: see text] The first chemical inhibitor of the 19S Regulatory Particle (RP) of the proteasome is described. The molecule was identified by screening a library of nucleoside-capped peptoids for binding to the yeast 26S proteasome in a crude extract. The hit was resynthesized and shown to block...

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מידע ביבליוגרפי
Main Authors: Lim, Hyun-Suk, Archer, Chase T., Kodadek, Thomas
פורמט: Artigo
שפה:Inglês
יצא לאור: 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543931/
https://ncbi.nlm.nih.gov/pubmed/17536803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja072027p
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