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Identification of a Peptoid Inhibitor of the Proteasome 19S Regulatory Particle
[Image: see text] The first chemical inhibitor of the 19S Regulatory Particle (RP) of the proteasome is described. The molecule was identified by screening a library of nucleoside-capped peptoids for binding to the yeast 26S proteasome in a crude extract. The hit was resynthesized and shown to block...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2543931/ https://ncbi.nlm.nih.gov/pubmed/17536803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja072027p |
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