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Periodate-Triggered Cross-Linking Reveals Sug2/Rpt4 as the Molecular Target of a Peptoid Inhibitor of the 19S Proteasome Regulatory Particle

This study describes the identification of the protein target of the first chemical inhibitor (RIP-1) of the 19S regulatory particle (RP) of the 26S proteasome. Periodate-triggered chemical cross-linking of DOPA-conjugated RIP-1 and the 26S proteasome identified Sug2/Rpt4, one of the six ATPases in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lim, Hyun-Suk, Cai, Di, Archer, Chase T., Kodadek, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544609/
https://ncbi.nlm.nih.gov/pubmed/17929816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja075469+
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