Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

BACKGROUND: Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed therapeutic agents, making it valuable to develop therapeutics that work by add...

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Pubblicato in:BMC Cancer
Autori principali: Ramirez, Ursula D., Nikonova, Anna S., Liu, Hanqing, Pecherskaya, Anna, Lawrence, Sarah H., Serebriiskii, Ilya G., Zhou, Yan, Robinson, Matthew K., Einarson, Margret B., Golemis, Erica A., Jaffe, Eileen K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451962/
https://ncbi.nlm.nih.gov/pubmed/26016476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1415-6
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