Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

BACKGROUND: Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed therapeutic agents, making it valuable to develop therapeutics that work by add...

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Detaylı Bibliyografya
Yayımlandı:BMC Cancer
Asıl Yazarlar: Ramirez, Ursula D., Nikonova, Anna S., Liu, Hanqing, Pecherskaya, Anna, Lawrence, Sarah H., Serebriiskii, Ilya G., Zhou, Yan, Robinson, Matthew K., Einarson, Margret B., Golemis, Erica A., Jaffe, Eileen K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451962/
https://ncbi.nlm.nih.gov/pubmed/26016476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1415-6
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