Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies

Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked to therapeutic targets would be enriched for determinants of drug resistance. We developed a protein...

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Main Authors: Astsaturov, Igor, Ratushny, Vladimir, Sukhanova, Anna, Einarson, Margret B., Bagnyukova, Tetyana, Zhou, Yan, Devarajan, Karthik, Silverman, Joshua S., Tikhmyanova, Nadezhda, Skobeleva, Natalya, Pecherskaya, Anna, Nasto, Rochelle E., Sharma, Catherine, Jablonski, Sandra A., Serebriiskii, Ilya G., Weiner, Louis M., Golemis, Erica A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950064/
https://ncbi.nlm.nih.gov/pubmed/20858866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001083
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