Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies

Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked to therapeutic targets would be enriched for determinants of drug resistance. We developed a protein...

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Detalhes bibliográficos
Main Authors: Astsaturov, Igor, Ratushny, Vladimir, Sukhanova, Anna, Einarson, Margret B., Bagnyukova, Tetyana, Zhou, Yan, Devarajan, Karthik, Silverman, Joshua S., Tikhmyanova, Nadezhda, Skobeleva, Natalya, Pecherskaya, Anna, Nasto, Rochelle E., Sharma, Catherine, Jablonski, Sandra A., Serebriiskii, Ilya G., Weiner, Louis M., Golemis, Erica A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950064/
https://ncbi.nlm.nih.gov/pubmed/20858866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001083
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