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Mechanisms of tumor resistance to EGFR-targeted therapies

BACKGROUND: Much effort has been devoted to development of cancer therapies targeting EGFR, based on its role in regulating cell growth. Small-molecule and antibody EGFR inhibitors have clinical roles based on their efficacy in a subset of cancers, generally as components of combination therapies. M...

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Detalhes bibliográficos
Main Authors: Hopper-Borge, Elizabeth A, Nasto, Rochelle E, Ratushny, Vladimir, Weiner, Louis M, Golemis, Erica A, Astsaturov, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670612/
https://ncbi.nlm.nih.gov/pubmed/19236156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14712590902735795
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