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Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?

In recent years, oncologists have begun to conclude that chemotherapy has reached a plateau of efficacy as a primary treatment modality, even if toxicity can be effectively controlled. Emerging specific inhibitors of signaling and metabolic pathways (i.e., targeted agents) contrast with traditional...

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Autori principali: Bagnyukova, Tetyana, Serebriiskii, Ilya G, Zhou, Yan, Hopper-Borge, Elizabeth A, Golemis, Erica A, Astsaturov, Igor
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012138/
https://ncbi.nlm.nih.gov/pubmed/20935499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.9.13738
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