Protein Kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III–IV linker

Resurgent sodium currents likely play a role in modulating neuronal excitability. Here we studied whether protein kinase C (PKC) activation can increase resurgent currents produced by the human sodium channel hNav1.7. We found that a PKC agonist significantly enhanced hNav1.7-mediated resurgent curr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:FEBS Lett
Prif Awduron: Tan, Zhi-Yong, Priest, Birgit T., Krajewski, Jeffrey L., Knopp, Kelly L., Nisenbaum, Eric S., Cummins, Theodore R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451938/
https://ncbi.nlm.nih.gov/pubmed/25240195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.09.011
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