Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

Inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD) are inherited pain syndromes predominantly caused by missense mutations in the peripheral neuronal voltage-gated sodium channel (Nav) isoform Nav1.7. While both IEM and PEPD mutations increase neuronal excitability, IEM muta...

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Detalhes bibliográficos
Main Authors: Theile, Jonathan W, Jarecki, Brian W, Piekarz, Andrew D, Cummins, Theodore R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055545/
https://ncbi.nlm.nih.gov/pubmed/21115638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.200915
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