Inhibition of Navβ4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide

Paroxysmal extreme pain disorder (PEPD) and inherited erythromelalgia (IEM) are inherited pain syndromes arising from different sets of gain-of-function mutations in the sensory neuronal sodium channel isoform Nav1.7. Mutations associated with PEPD, but not IEM, result in destabilized inactivation o...

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Bibliographische Detailangaben
Hauptverfasser: Theile, Jonathan W., Cummins, Theodore R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187525/
https://ncbi.nlm.nih.gov/pubmed/21788423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.072751
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