Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction

Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials (APs). Two brain isoforms, Nav1.1 and Nav1.6, have very distinct cellular and subcellular expression. Specifically, Nav1.1 is predominantly expressed in the soma and proximal axon initial segment of...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Patel, Reesha R., Barbosa, Cindy, Xiao, Yucheng, Cummins, Theodore R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504674/
https://ncbi.nlm.nih.gov/pubmed/26182346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133485
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