Paroxysmal extreme pain disorder mutations within the D3/S4–S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

Single-point missense mutations in the peripheral neuronal voltage-gated sodium channel Nav1.7 are implicated in the painful inherited neuropathy paroxysmal extreme pain disorder (PEPD). The Nav1.7 PEPD mutations are located in regions of the channel suggested to play important roles in fast inactiv...

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Detalhes bibliográficos
Main Authors: Jarecki, Brian W, Sheets, Patrick L, Jackson II, James O, Cummins, Theodore R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652197/
https://ncbi.nlm.nih.gov/pubmed/18599537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.154906
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