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Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels

BACKGROUND AND PURPOSE: The primary use of local anaesthetics is to prevent or relieve pain by reversibly preventing action potential propagation through the inhibition of voltage-gated sodium channels. The tetrodotoxin-sensitive voltage-gated sodium channel subtype Na(v)1.7, abundantly expressed in...

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Библиографические подробности
Главные авторы: Sheets, Patrick L, Jarecki, Brian W, Cummins, Theodore R
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188891/
https://ncbi.nlm.nih.gov/pubmed/21232038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01209.x
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