DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

Pre–B and pre–T lymphocytes must orchestrate a transition from a highly proliferative state to a quiescent one during development. Cyclin D3 is essential for these cells’ proliferation, but little is known about its posttranslational regulation at this stage. Here, we show that the dual specificity...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Thompson, Benjamin J., Bhansali, Rahul, Diebold, Lauren, Cook, Daniel E., Stolzenburg, Lindsay, Casagrande, Anne-Sophie, Besson, Thierry, Leblond, Bertrand, Désiré, Laurent, Malinge, Sébastien, Crispino, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451127/
https://ncbi.nlm.nih.gov/pubmed/26008897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150002
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