Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) hyperactivity has been linked to the development of a number of human malignancies. DYRK1A is the most studied family member, and the discovery of novel specific inhibitors is attracting considerable interest. The 8-cyclopropyl-2(py...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Fruit, Corinne, Couly, Florence, Bhansali, Rahul, Rammohan, Malini, Lindberg, Mattias F., Crispino, John D., Meijer, Laurent, Besson, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958357/
https://ncbi.nlm.nih.gov/pubmed/31861110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph12040185
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