Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains

In Eukarya, stalled translation induces 40S dissociation and recruitment of the Ribosome Quality control Complex (RQC) to the 60S subunit, which mediates nascent chain degradation. Here, we report cryoEM structures revealing that the RQC components Rqc2p (YPL009C/Tae2) and Ltn1p (YMR247C/Rkr1) bind...

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Publicado en:Science
Main Authors: Shen, Peter S., Park, Joseph, Qin, Yidan, Li, Xueming, Parsawar, Krishna, Larson, Matthew H., Cox, James, Cheng, Yifan, Lambowitz, Alan M., Weissman, Jonathan S., Brandman, Onn, Frost, Adam
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451101/
https://ncbi.nlm.nih.gov/pubmed/25554787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1259724
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