Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

Inflammasomes are critical for host defense against bacterial pathogens. In murine macrophages infected by gram-negative bacteria, the canonical inflammasome activates caspase-1 to mediate pyroptotic cell death and release of IL-1 family cytokines. Additionally, a noncanonical inflammasome controlle...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Casson, Cierra N., Yu, Janet, Reyes, Valeria M., Taschuk, Frances O., Yadav, Anjana, Copenhaver, Alan M., Nguyen, Hieu T., Collman, Ronald G., Shin, Sunny
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450384/
https://ncbi.nlm.nih.gov/pubmed/25964352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421699112
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