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Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
Inflammasomes are critical for host defense against bacterial pathogens. In murine macrophages infected by gram-negative bacteria, the canonical inflammasome activates caspase-1 to mediate pyroptotic cell death and release of IL-1 family cytokines. Additionally, a noncanonical inflammasome controlle...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4450384/ https://ncbi.nlm.nih.gov/pubmed/25964352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421699112 |
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