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Effects of alcohol on human carboxylesterase drug metabolism

BACKGROUND AND OBJECTIVE: Human carboxylesterase-1 (CES1) and human carboxylesterase-2 (CES2) play an important role in metabolizing many medications. Alcohol is a known inhibitor of these enzymes but the relative effect on CES1 and CES2 is unknown. The aim of this study is to determine the impact o...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: Parker, Robert B., Hu, Zhe-Yi, Meibohm, Bernd, Laizure, S. Casey
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450114/
https://ncbi.nlm.nih.gov/pubmed/25511794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0226-2
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