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The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
Carboxylesterases are a multi-gene family of enzymes widely distributed throughout the body of mammals that catalyze the hydrolysis of esters, amides, thioesters, and carbamates. In humans, two carboxylesterases, hCE1 and hCE2, are important pathways of drug metabolism. Both are expressed in the liv...
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| Publicado en: | Pharmacotherapy |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4572478/ https://ncbi.nlm.nih.gov/pubmed/23386599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.1194 |
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