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Identification of Carboxylesterase-Dependent Dabigatran Etexilate Hydrolysis
Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted to the active thrombin inhibitor, dabigatran (DAB), by serine esterases. The aims of the present study were to investigate the in vitro kinetics and pathway of DABE hydrolysis by human carboxylesterase enzymes, and the effect o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3912543/ https://ncbi.nlm.nih.gov/pubmed/24212379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054353 |
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