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Promiscuity progression of bioactive compounds over time

In the context of polypharmacology, compound promiscuity is rationalized as the ability of small molecules to specifically interact with multiple targets. To study promiscuity progression of bioactive compounds in detail, nearly 1 million compounds and more than 5.2 million activity records were ana...

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Pubblicato in:F1000Res
Autori principali: Hu, Ye, Jasial, Swarit, Bajorath, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: F1000Research 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448747/
https://ncbi.nlm.nih.gov/pubmed/26064479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.6473.1
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