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Quantifying the Tendency of Therapeutic Target Proteins to Bind Promiscuous or Selective Compounds

The ability of target proteins to bind structurally diverse compounds and compounds with different degrees of promiscuity (multi-target activity) was systematically assessed on the basis of currently available activity data and target annotations. Intuitive first- and second-order target promiscuity...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Hu, Ye, Bajorath, Jürgen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441477/
https://ncbi.nlm.nih.gov/pubmed/26000736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126838
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