Exploring Compound Promiscuity Patterns and Multi-Target Activity Spaces

Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology. This concise review focu...

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Bibliographic Details
Main Authors: Hu, Ye, Gupta-Ostermann, Disha, Bajorath, Jürgen
Format: Artigo
Language:Inglês
Published: Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2014
Subjects:
Mini Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962225/
https://ncbi.nlm.nih.gov/pubmed/24688751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5936/csbj.201401003
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