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Scalable syntheses of the BET bromodomain inhibitor JQ1
We have developed methods involving the use of alternate, safer reagents for the scalable syntheses of the potent BET bromodomain inhibitor JQ1. A one-pot three step method, involving the conversion of a benzodiazepine to a thioamde using Lawesson’s reagent, followed by amidrazone formation and inst...
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| 出版年: | Tetrahedron Lett |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4448696/ https://ncbi.nlm.nih.gov/pubmed/26034331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.02.062 |
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