Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer

Inhibitors of bromodomain and extraterminal domain (BET) proteins, a family of chromatin reader proteins, have therapeutic efficacy against various malignancies. However, the detailed mechanisms underlying the anti-tumor effects in distinct tumor types remain elusive. Here, we show a novel antitumor...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yamamoto, Keisuke, Tateishi, Keisuke, Kudo, Yotaro, Hoshikawa, Mayumi, Tanaka, Mariko, Nakatsuka, Takuma, Fujiwara, Hiroaki, Miyabayashi, Koji, Takahashi, Ryota, Tanaka, Yasuo, Ijichi, Hideaki, Nakai, Yousuke, Isayama, Hiroyuki, Morishita, Yasuyuki, Aoki, Taku, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Fukayama, Masashi, Koike, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308665/
https://ncbi.nlm.nih.gov/pubmed/27528027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11129
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