Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer

Pancreatic cancer is one of the malignant diseases with the worst prognosis. Resistance to chemotherapy is a major difficulty in treating the disease. We analyzed plasma samples from a genetically engineered mouse model of pancreatic cancer and found soluble vascular cell adhesion molecule-1 (sVCAM-...

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Publicado no:Sci Rep
Main Authors: Takahashi, Ryota, Ijichi, Hideaki, Sano, Makoto, Miyabayashi, Koji, Mohri, Dai, Kim, Jinsuk, Kimura, Gen, Nakatsuka, Takuma, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Tanaka, Yasuo, Tateishi, Keisuke, Nakai, Yousuke, Morishita, Yasuyuki, Soma, Katsura, Takeda, Norihiko, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713301/
https://ncbi.nlm.nih.gov/pubmed/33273652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78320-3
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