Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction (desmoplasia). We have previously reported that mice with conditional Kras(G12D) mutation and knockout of TGF-β receptor type II (Tgfbr2), PKF mice, develop PDAC with desmoplasia modulated by CXC chemokines that are p...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Sano, Makoto, Ijichi, Hideaki, Takahashi, Ryota, Miyabayashi, Koji, Fujiwara, Hiroaki, Yamada, Tomoharu, Kato, Hiroyuki, Nakatsuka, Takuma, Tanaka, Yasuo, Tateishi, Keisuke, Morishita, Yasuyuki, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338726/
https://ncbi.nlm.nih.gov/pubmed/30659170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0117-8
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