Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously generated pancreas epithelium–specific TGF-β receptor type II (Tgfbr2) knockout mice in the context of Kras activation (mice referred to...

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Detalhes bibliográficos
Main Authors: Ijichi, Hideaki, Chytil, Anna, Gorska, Agnieszka E., Aakre, Mary E., Bierie, Brian, Tada, Motohisa, Mohri, Dai, Miyabayashi, Koji, Asaoka, Yoshinari, Maeda, Shin, Ikenoue, Tsuneo, Tateishi, Keisuke, Wright, Christopher V.E., Koike, Kazuhiko, Omata, Masao, Moses, Harold L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195452/
https://ncbi.nlm.nih.gov/pubmed/21926469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42754
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