Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously generated pancreas epithelium–specific TGF-β receptor type II (Tgfbr2) knockout mice in the context of Kras activation (mice referred to...

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Bibliografiset tiedot
Päätekijät: Ijichi, Hideaki, Chytil, Anna, Gorska, Agnieszka E., Aakre, Mary E., Bierie, Brian, Tada, Motohisa, Mohri, Dai, Miyabayashi, Koji, Asaoka, Yoshinari, Maeda, Shin, Ikenoue, Tsuneo, Tateishi, Keisuke, Wright, Christopher V.E., Koike, Kazuhiko, Omata, Masao, Moses, Harold L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2011
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195452/
https://ncbi.nlm.nih.gov/pubmed/21926469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42754
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