Identification of a Suppressive Mechanism for Hedgehog Signaling through a Novel Interaction of Gli with 14-3-3

Gli transcription factors are central effectors of Hedgehog signaling in development and tumorigenesis. Using a tandem affinity purification (TAP) strategy and mass spectrometry, we have found that Gli1 interacts with 14-3-3ϵ, and that Gli2 and Gli3 also bind to 14-3-3ϵ through homologous sites. Thi...

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Detalhes bibliográficos
Main Authors: Asaoka, Yoshinari, Kanai, Fumihiko, Ichimura, Tohru, Tateishi, Keisuke, Tanaka, Yasuo, Ohta, Miki, Seto, Motoko, Tada, Motohisa, Ijichi, Hideaki, Ikenoue, Tsuneo, Kawabe, Takao, Isobe, Toshiaki, Yaffe, Michael B., Omata, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823557/
https://ncbi.nlm.nih.gov/pubmed/19996099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038232
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