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Identification of a Suppressive Mechanism for Hedgehog Signaling through a Novel Interaction of Gli with 14-3-3
Gli transcription factors are central effectors of Hedgehog signaling in development and tumorigenesis. Using a tandem affinity purification (TAP) strategy and mass spectrometry, we have found that Gli1 interacts with 14-3-3ϵ, and that Gli2 and Gli3 also bind to 14-3-3ϵ through homologous sites. Thi...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823557/ https://ncbi.nlm.nih.gov/pubmed/19996099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038232 |
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