Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression

Pancreatic ductal adenocarcinoma (PDAC) is an almost uniformly lethal disease in humans. Transforming growth factor-β (TGF-β) signaling plays an important role in PDAC progression, as indicated by the fact that Smad4, which encodes a central signal mediator downstream from TGF-β, is deleted or mutat...

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Detalhes bibliográficos
Main Authors: Ijichi, Hideaki, Chytil, Anna, Gorska, Agnieszka E., Aakre, Mary E., Fujitani, Yoshio, Fujitani, Shuko, Wright, Christopher V.E., Moses, Harold L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635149/
https://ncbi.nlm.nih.gov/pubmed/17114585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1475506
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