Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation

The transcription factor pancreatic and duodenal homeobox factor 1 (PDX-1) is expressed in pancreatic progenitor cells. In exocrine pancreas, PDX-1 is down-regulated during late development, while re-up-regulation of PDX-1 has been reported in pancreatic cancer and pancreatitis. To determine whether...

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Detalhes bibliográficos
Main Authors: Miyatsuka, Takeshi, Kaneto, Hideaki, Shiraiwa, Toshihiko, Matsuoka, Taka-aki, Yamamoto, Kaoru, Kato, Ken, Nakamura, Yumiko, Akira, Shizuo, Takeda, Kiyoshi, Kajimoto, Yoshitaka, Yamasaki, Yoshimitsu, Sandgren, Eric P., Kawaguchi, Yoshiya, Wright, Christopher V.E., Fujitani, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1475756/
https://ncbi.nlm.nih.gov/pubmed/16751181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1412806
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