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Increasing Fragmentation of Disulfide-Bonded Proteins for Top-Down Mass Spectrometry by Supercharging

The disulfide bond is an important post-translational modification to form and maintain the native structure and biological functions of proteins. Characterization of disulfide bond linkages is therefore of essential interest in the structural elucidation of proteins. Top-down mass spectrometry (MS)...

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Detalles Bibliográficos
Publicado en:Int J Mass Spectrom
Main Authors: Zhang, Jiang, Ogorzalek Loo, Rachel R., Loo, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448141/
https://ncbi.nlm.nih.gov/pubmed/26028988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2014.07.047
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