A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma

Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed understanding of the molecular and physiological mechanisms through which these genes affect disease phenotypes remains a major challenge. Here, we...

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Udgivet i:Hum Mol Genet
Main Authors: Sharma, Amitabh, Menche, Jörg, Huang, C. Chris, Ort, Tatiana, Zhou, Xiaobo, Kitsak, Maksim, Sahni, Nidhi, Thibault, Derek, Voung, Linh, Guo, Feng, Ghiassian, Susan Dina, Gulbahce, Natali, Baribaud, Frédéric, Tocker, Joel, Dobrin, Radu, Barnathan, Elliot, Liu, Hao, Panettieri, Reynold A., Tantisira, Kelan G., Qiu, Weiliang, Raby, Benjamin A., Silverman, Edwin K., Vidal, Marc, Weiss, Scott T., Barabási, Albert-László
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447811/
https://ncbi.nlm.nih.gov/pubmed/25586491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv001
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