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Integrating personalized gene expression profiles into predictive disease-associated gene pools

Gene expression data are routinely used to identify genes that on average exhibit different expression levels between a case and a control group. Yet, very few of such differentially expressed genes are detectably perturbed in individual patients. Here, we develop a framework to construct personaliz...

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Detalhes bibliográficos
Publicado no:NPJ Syst Biol Appl
Main Authors: Menche, Jörg, Guney, Emre, Sharma, Amitabh, Branigan, Patrick J., Loza, Matthew J., Baribaud, Frédéric, Dobrin, Radu, Barabási, Albert-László
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445628/
https://ncbi.nlm.nih.gov/pubmed/28649437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0009-0
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