Activating MET Kinase Rearrangements in Melanoma and Spitz Tumors

Oncogenic gene fusions have been identified in many cancers and many serve as biomarkers or targets for therapy. Here we identify six different melanocytic tumors with genomic rearrangements of MET fusing the kinase domain of MET in-frame to six different N-terminal partners. These tumors lack activ...

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Vydáno v:Nat Commun
Hlavní autoři: Yeh, Iwei, Botton, Thomas, Talevich, Eric, Shain, A. Hunter, Sparatta, Alyssa J., de la Fouchardiere, Arnaud, Mully, Thaddeus W., North, Jeffrey P., Garrido, Maria C., Gagnon, Alexander, Vemula, Swapna S., McCalmont, Timothy H., LeBoit, Philip E., Bastian, Boris C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446791/
https://ncbi.nlm.nih.gov/pubmed/26013381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8174
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