Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy

BRAF is the most prevalent oncogene and an important therapeutic target in melanoma. In some cancers BRAF is activated by rearrangements that fuse its kinase domain to 5’ partner genes. We examined 848 comparative genomic hybridization profiles of melanocytic tumors and found copy number transitions...

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Bibliografiska uppgifter
Huvudupphovsmän: Botton, Thomas, Yeh, Iwei, Nelson, Tyrrell, Vemula, Swapna S., Sparatta, Alyssa, Garrido, Maria C., Allegra, Maryline, Rocchi, Stephane, Bahadoran, Philippe, McCalmont, Timothy H., LeBoit, Philip E., Burton, Elizabeth A., Bollag, Gideon, Ballotti, Robert, Bastian, Boris C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808507/
https://ncbi.nlm.nih.gov/pubmed/23890088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12148
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