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Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy

BRAF is the most prevalent oncogene and an important therapeutic target in melanoma. In some cancers BRAF is activated by rearrangements that fuse its kinase domain to 5’ partner genes. We examined 848 comparative genomic hybridization profiles of melanocytic tumors and found copy number transitions...

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書誌詳細
主要な著者: Botton, Thomas, Yeh, Iwei, Nelson, Tyrrell, Vemula, Swapna S., Sparatta, Alyssa, Garrido, Maria C., Allegra, Maryline, Rocchi, Stephane, Bahadoran, Philippe, McCalmont, Timothy H., LeBoit, Philip E., Burton, Elizabeth A., Bollag, Gideon, Ballotti, Robert, Bastian, Boris C.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808507/
https://ncbi.nlm.nih.gov/pubmed/23890088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12148
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