RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Kar, Ananya, Kaur, Manpreet, Ghosh, Tanushree, Khan, Md. Muntaz, Sharma, Aparna, Shekhar, Ritu, Varshney, Akhil, Saxena, Sandeep
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446429/
https://ncbi.nlm.nih.gov/pubmed/25916848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv369
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