RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Kar, Ananya, Kaur, Manpreet, Ghosh, Tanushree, Khan, Md. Muntaz, Sharma, Aparna, Shekhar, Ritu, Varshney, Akhil, Saxena, Sandeep
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446429/
https://ncbi.nlm.nih.gov/pubmed/25916848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv369
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