RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kar, Ananya, Kaur, Manpreet, Ghosh, Tanushree, Khan, Md. Muntaz, Sharma, Aparna, Shekhar, Ritu, Varshney, Akhil, Saxena, Sandeep
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446429/
https://ncbi.nlm.nih.gov/pubmed/25916848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv369
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