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RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling
The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated...
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| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4446429/ https://ncbi.nlm.nih.gov/pubmed/25916848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv369 |
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