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The relationship of autophagy defects and cartilage damage during joint aging in a mouse model

OBJECTIVES: Aging is a main risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disorder. Defects in autophagy, an essential cellular homeostasis mechanism, have recently been observed in OA articular cartilage. The objectives of this study were to establish the constitutive leve...

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Publicado en:Arthritis Rheumatol
Main Authors: Caramés, Beatriz, Olmer, Merissa, Kiosses, William B., Lotz, Martin
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446178/
https://ncbi.nlm.nih.gov/pubmed/25708836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39073
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