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Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism

OBJECTIVES: Aging is an important osteoarthritis (OA) risk factor and compromised stress defense responses may mediate this risk. The Sestrins (Sesn) promote cell survival under stress conditions and regulate AMPK and mTOR signaling. This study examined Sesn expression in normal and OA cartilage and...

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Detalhes bibliográficos
Publicado no:Osteoarthritis Cartilage
Main Authors: Shen, Tao, Alvarez-Garcia, Oscar, Li, Yan, Olmer, Merissa, Lotz, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5258682/
https://ncbi.nlm.nih.gov/pubmed/27693501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.09.017
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