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Insights into Cytokine–Receptor Interactions from Cytokine Engineering

Cytokines exert a vast array of immunoregulatory actions critical to human biology and disease. However, the desired immunotherapeutic effects of native cytokines are often mitigated by toxicity or lack of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activatio...

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Bibliografske podrobnosti
izdano v:Annu Rev Immunol
Main Authors: Spangler, Jamie B., Moraga, Ignacio, Mendoza, Juan L., Garcia, K. Christopher
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445396/
https://ncbi.nlm.nih.gov/pubmed/25493332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-immunol-032713-120211
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