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Insights into Cytokine–Receptor Interactions from Cytokine Engineering

Cytokines exert a vast array of immunoregulatory actions critical to human biology and disease. However, the desired immunotherapeutic effects of native cytokines are often mitigated by toxicity or lack of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activatio...

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Bibliografiska uppgifter
I publikationen:Annu Rev Immunol
Huvudupphovsmän: Spangler, Jamie B., Moraga, Ignacio, Mendoza, Juan L., Garcia, K. Christopher
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445396/
https://ncbi.nlm.nih.gov/pubmed/25493332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-immunol-032713-120211
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