Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor

Chemokines are small proteins that function as immune modulators through activation of chemokine G protein–coupled receptors (GPCRs). Several viruses also encode chemokines and chemokine receptors to subvert the host immune response. How protein ligands activate GPCRs remains unknown. We report the...

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Publicat a:Science
Autors principals: Burg, John S., Ingram, Jessica R., Venkatakrishnan, A. J., Jude, Kevin M., Dukkipati, Abhiram, Feinberg, Evan N., Angelini, Alessandro, Waghray, Deepa, Dror, Ron O., Ploegh, Hidde L., Garcia, K. Christopher
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445376/
https://ncbi.nlm.nih.gov/pubmed/25745166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5026
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